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高嘉鴻/醫學系CLINICAL INFECTIOUS DISEASES. 2020 Jun 6;71(10)：2695-2701Risk of Viral Infection in Patients Using Either Angiotensin-converting Enzyme Inhibitors or Angiotensin Receptor Blockers: A Nationwide Population-based Propensity Score Matching StudyBackground: We hypothesized that renin-angiotensin system (RAS) blockers have systemic protective effects beyond the respiratory tract and could reduce the risk of viral infections. |
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陳世殷/中醫學系THERANOSTICS. 2020 Oct 26;10(26):12026-12043.Somatic mutational landscapes of adherens junctions and their functional consequences in cutaneous melanoma developmentCell-cell interaction in skin homeostasis is tightly controlled by adherens junctions (AJs). Alterations in such regulation lead to melanoma development. However, mutations in AJs and their functional consequences are still largely unknown. |
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佘玉萍/生物醫學研究所THERANOSTICS. 2020 Aug 29;10(24):10925-10939.Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progressionRationale: Brain metastasis in patients with lung cancer is life-threatening. However, the molecular mechanism for this catastrophic disease remains elusive, and few druggable targets are available. Therefore, this study aimed to identify and characterize |
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洪慧珊/生物醫學研究所ACS APPLIED MATERIALS & INTERFACES. 2020 Oct 7;12(40):44393-44406.Enhanced Biocompatibility and Differentiation Capacity of Mesenchymal Stem Cells on Poly(dimethylsiloxane) by Topographically Patterned DopamineControlling the behavior of mesenchymal stem cells (MSCs) through topographic patterns is an effective approach for stem cell studies. |
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許翺麟/老化醫學博士學位學程SCIENCE ADVANCES. 2020 Oct 21;6(43):eaaz4452HSB-1/HSF-1 pathway modulates histone H4 in mitochondria to control mtDNA transcription and longevityHeat shock factor-1 (HSF-1) is a master regulator of stress responses across taxa. Overexpression of HSF-1 or genetic ablation of its conserved negative regulator, heat shock factor binding protein 1 (HSB-1), results in robust life-span extension in Caeno |
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劉彥良/生物醫學工程碩士學位學程ACS NANO. 2020 Jul 28;14(7):7927-7939.Three-Dimensional Two-Color Dual-Particle Tracking Microscope for Monitoring DNA Conformational Changes and Nanoparticle Landings on Live CellsHere, we present a three-dimensional two-color dual-particle tracking (3D-2C-DPT) technique that can simultaneously localize two spectrally distinct targets in three dimensions with a time resolution down to 5 ms. |
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王志豪/生物醫學研究所SCIENCE TRANSLATIONAL MEDICINE. 2020 Aug；12(558)CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in miceBrown and brown-like beige/brite adipocytes dissipate energy and have been proposed as therapeutic targets to combat metabolic disorders. However, the therapeutic effects of cell-based therapy in humans remain unclear. Here, we created human brown-like (H |
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洪明奇/校長JACC-CARDIOVASCULAR INTERVENTIONS. 2020 Aug 10;13(15)New Approaches on Cancer ImmunotherapyMetastasis, which occurs when cancer cells disseminate from the primary tumor site to other parts of the body, is the primary cause of mortality in patients, and the recurrence of multiple metastatic tumors is an obstacle to eliminating cancer. |
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洪明奇/校長NATURE CELL BIOLOGY. 2020 Oct ;22(10):1264-+PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosisAlthough pyroptosis is critical for macrophages against pathogen infection, its role and mechanism in cancer cells remains unclear. |
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陳建良/藥學系Biosens Bioelectron. 2020 Mar 1;151:111965Fluorometric determination of amifostine and alkaline phosphatase on amphiprotic molecularly imprinted silica crosslinked with binary functional silanes and carbon dotsA silica-based molecularly imprinted polymer (MIP) formed by functional silanes (basic 3-aminopropyltriethoxysilane (APTES) and acidic 2-(4-chlorosulfonylphenyl)ethyltrimethoxysilane (CSPTMS)) was crosslinked with carbon dots (CDs) to develop a fluorescen |
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徐婕琳/生物醫學研究所EMBO Mol Med. 2020 Jan 9;12(1):e9386Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitisHuman caspase-4 and its mouse homolog caspase-11 are receptors for cytoplasmic lipopolysaccharide. |
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洪靚娟/藥學院Phytomedicine. 2020 Jun;71:153239Wilforine resensitizes multidrug resistant cancer cells via competitive inhibition of P-glycoproteinBackground and purpose: Multidrug resistance (MDR) remains the main obstacle in cancer treatment and over-expression of P-glycoprotein (P-gp) is one of the most common causes of chemoresistance. The development of novel P-gp inhibitors from natural produc |
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洪明奇/校長ACS Sens. 2020 Feb 28;5(2):296-302Digital Receptor Occupancy Assay in Quantifying On- and Off-Target Binding Affinities of Therapeutic AntibodiesWhile monoclonal antibodies are the fastest-growing class of therapeutic agents, we lack a method that can directly quantify the on- and off-target binding affinities of newly developed therapeutic antibodies in crude cell lysates. |
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黃彬芳/職業安全與衛生學系Environ Int. 2020 May;138:105602Exposure to fine particulate matter (PM2.5) and pediatric rheumatic diseasesFew studies have assessed the association between fine particulate matter (PM2.5) exposure during pregnancy and infancy and pediatric rheumatic diseases (PRDs). The goal of this study was to investigate the association of PM2.5 with PRDs, and to explore s |
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洪明奇/校長Theranostics. 2020 Mar 25;10(10)SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathwayHepatocellular carcinoma (HCC) remains one of the most refractory malignancies worldwide. Schlafen family member 11 (SLFN11) has been reported to play an important role in inhibiting the production of human immunodeficiency virus 1 (HIV-1). However, wheth |
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洪明奇/校長Cancer Res. 2020 Jun 1;80(11):2298-2310Targeting Glycosylated PD-1 Induces Potent Antitumor ImmunityImmunotherapies targeting programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1) immune checkpoints represent a major breakthrough in cancer treatment. |
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彭成元/醫學系Clin Infect Dis. 2020 Jan 1;70(1):114-122Performance of Acoustic Radiation Force Impulse Elastography for Staging Liver Fibrosis in Patients With Chronic Hepatitis C After Viral EradicationBackground. Data on noninvasive liver fibrosis staging after viral eradication are unclear. This histology-based study validated the performance of liver stiffness (LS) measurements after viral eradication. |
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鄭維中/生物醫學研究所Nucleic Acids Res. 2020 Jan 8;48(D1):D863-D870DriverDBv3: a multi-omics database for cancer driver gene researchAn integrative multi-omics database is needed urgently, because focusing only on analysis of one-dimensional data falls far short of providing an understanding of cancer. |
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洪明奇/校長Nature. 2020 Apr;580(7804):530-535The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesisPhosphorylation of INSIG1 and INSIG2 by PCK1 leads to a reduction in the binding of sterols, the activation of SREBP1 and SREBP2 and the downstream transcription of lipogenesis-associated genes that promote tumour growth. |