New Approaches on Cancer Immunotherapy

作者/單位: 洪明奇/校長
期刊名稱: JACC-CARDIOVASCULAR INTERVENTIONS
IF值: 8.432
領域排名: CARDIAC & CARDIOVASCULAR SYSTEMS  (11/138)   7.9%
文章摘要: 

Metastasis, which occurs when cancer cells disseminate from the primary tumor site to other parts of the body, is the primary cause of mortality in patients, and the recurrence of multiple metastatic tumors is an obstacle to eliminating cancer. Recent clinical studies demonstrated that patients who respond to immunotherapy have longer survival rates with lower metastatic relapse, suggesting that immunotherapy may be one of the solutions to overcome cancer metastasis. Indeed, various host immune cells not only shape the tumor microenvironment but also participate in multiple stages of metastasis. Therefore, to improve clinical outcome, it is critical to understand the immunological events associated with tumor development and progression. In this article, we summarize those events that are involved in tumor progression and discuss immunotherapies that can potentially target cancer metastasis.

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發表者簡介


單位:校長室 校長

研究專長:

  • 酪胺酸激酶受體(Receptor Tyrosine Kinase)在癌症領域之前沿研究
  • 解析腫瘤發展、轉移及抗藥性產生的訊息傳遞途徑及表觀調控機制
  • 針對困難癌症開發新穎免疫及標靶治療
  • 建立新的分子生物標記,推動個人化精準醫療

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