CLINICAL INFECTIOUS DISEASES. 2020 Jun 6;71(10):2695-2701
Risk of Viral Infection in Patients Using Either Angiotensin-converting Enzyme Inhibitors or Angiotensin Receptor Blockers: A Nationwide Population-based Propensity Score Matching Study
Background: We hypothesized that renin-angiotensin system (RAS) blockers have systemic protective effects beyond the respiratory tract and could reduce the risk of viral infections.
THERANOSTICS. 2020 Oct 26;10(26):12026-12043.
Somatic mutational landscapes of adherens junctions and their functional consequences in cutaneous melanoma development
Cell-cell interaction in skin homeostasis is tightly controlled by adherens junctions (AJs). Alterations in such regulation lead to melanoma development. However, mutations in AJs and their functional consequences are still largely unknown.
THERANOSTICS. 2020 Aug 29;10(24):10925-10939.
Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression
Rationale: Brain metastasis in patients with lung cancer is life-threatening. However, the molecular mechanism for this catastrophic disease remains elusive, and few druggable targets are available. Therefore, this study aimed to identify and characterize
ACS APPLIED MATERIALS & INTERFACES. 2020 Oct 7;12(40):44393-44406.
Enhanced Biocompatibility and Differentiation Capacity of Mesenchymal Stem Cells on Poly(dimethylsiloxane) by Topographically Patterned Dopamine
Controlling the behavior of mesenchymal stem cells (MSCs) through topographic patterns is an effective approach for stem cell studies.
SCIENCE ADVANCES. 2020 Oct 21;6(43):eaaz4452
HSB-1/HSF-1 pathway modulates histone H4 in mitochondria to control mtDNA transcription and longevity
Heat shock factor-1 (HSF-1) is a master regulator of stress responses across taxa. Overexpression of HSF-1 or genetic ablation of its conserved negative regulator, heat shock factor binding protein 1 (HSB-1), results in robust life-span extension in Caeno
ACS NANO. 2020 Jul 28;14(7):7927-7939.
Three-Dimensional Two-Color Dual-Particle Tracking Microscope for Monitoring DNA Conformational Changes and Nanoparticle Landings on Live Cells
Here, we present a three-dimensional two-color dual-particle tracking (3D-2C-DPT) technique that can simultaneously localize two spectrally distinct targets in three dimensions with a time resolution down to 5 ms.
CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice
Brown and brown-like beige/brite adipocytes dissipate energy and have been proposed as therapeutic targets to combat metabolic disorders. However, the therapeutic effects of cell-based therapy in humans remain unclear. Here, we created human brown-like (H
New Approaches on Cancer Immunotherapy
Metastasis, which occurs when cancer cells disseminate from the primary tumor site to other parts of the body, is the primary cause of mortality in patients, and the recurrence of multiple metastatic tumors is an obstacle to eliminating cancer.
NATURE CELL BIOLOGY. 2020 Oct ;22(10):1264-+
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis
Although pyroptosis is critical for macrophages against pathogen infection, its role and mechanism in cancer cells remains unclear.
Biosens Bioelectron. 2020 Mar 1;151:111965
Fluorometric determination of amifostine and alkaline phosphatase on amphiprotic molecularly imprinted silica crosslinked with binary functional silanes and carbon dots
A silica-based molecularly imprinted polymer (MIP) formed by functional silanes (basic 3-aminopropyltriethoxysilane (APTES) and acidic 2-(4-chlorosulfonylphenyl)ethyltrimethoxysilane (CSPTMS)) was crosslinked with carbon dots (CDs) to develop a fluorescen
EMBO Mol Med. 2020 Jan 9;12(1):e9386
Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitis
Human caspase-4 and its mouse homolog caspase-11 are receptors for cytoplasmic lipopolysaccharide.
Phytomedicine. 2020 Jun;71:153239
Wilforine resensitizes multidrug resistant cancer cells via competitive inhibition of P-glycoprotein
Background and purpose: Multidrug resistance (MDR) remains the main obstacle in cancer treatment and over-expression of P-glycoprotein (P-gp) is one of the most common causes of chemoresistance. The development of novel P-gp inhibitors from natural produc
ACS Sens. 2020 Feb 28;5(2):296-302
Digital Receptor Occupancy Assay in Quantifying On- and Off-Target Binding Affinities of Therapeutic Antibodies
While monoclonal antibodies are the fastest-growing class of therapeutic agents, we lack a method that can directly quantify the on- and off-target binding affinities of newly developed therapeutic antibodies in crude cell lysates.
Environ Int. 2020 May;138:105602
Exposure to fine particulate matter (PM2.5) and pediatric rheumatic diseases
Few studies have assessed the association between fine particulate matter (PM2.5) exposure during pregnancy and infancy and pediatric rheumatic diseases (PRDs). The goal of this study was to investigate the association of PM2.5 with PRDs, and to explore s
Theranostics. 2020 Mar 25;10(10)
SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway
Hepatocellular carcinoma (HCC) remains one of the most refractory malignancies worldwide. Schlafen family member 11 (SLFN11) has been reported to play an important role in inhibiting the production of human immunodeficiency virus 1 (HIV-1). However, wheth
Cancer Res. 2020 Jun 1;80(11):2298-2310
Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity
Immunotherapies targeting programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1) immune checkpoints represent a major breakthrough in cancer treatment.
Clin Infect Dis. 2020 Jan 1;70(1):114-122
Performance of Acoustic Radiation Force Impulse Elastography for Staging Liver Fibrosis in Patients With Chronic Hepatitis C After Viral Eradication
Background. Data on noninvasive liver fibrosis staging after viral eradication are unclear. This histology-based study validated the performance of liver stiffness (LS) measurements after viral eradication.
Nucleic Acids Res. 2020 Jan 8;48(D1):D863-D870
DriverDBv3: a multi-omics database for cancer driver gene research
An integrative multi-omics database is needed urgently, because focusing only on analysis of one-dimensional data falls far short of providing an understanding of cancer.
Nature. 2020 Apr;580(7804):530-535
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis
Phosphorylation of INSIG1 and INSIG2 by PCK1 leads to a reduction in the binding of sterols, the activation of SREBP1 and SREBP2 and the downstream transcription of lipogenesis-associated genes that promote tumour growth.